Katoh M, Ozawa M, Akima T, Ikeda H, Fujii T, Ishii M
Development Research Laboratories, Banyu Pharmaceutical Co., Ltd., Japan.
Jikken Dobutsu. 1992 Jul;41(3):329-37. doi: 10.1538/expanim1978.41.3_329.
Hematological and serum biochemical values of dams and offspring of Sprague-Dawley rats were measured during late gestation, lactation and postweaning. In dams, slightly low erythrocytic parameters, high platelets and high frequency of neutrophils were seen after parturition although WBC showed no marked changes. On Day 20 of gestation, glucose and triglycerides were extremely high and TP and albumin were low. These changes may be attributed to pregnancy or parturition. In fetuses on Day 20 of gestation and offspring immediately after birth, erythrocytes showed anisocytosis, polychromasia, basophilic stipplings and Howell-Jolly bodies and erythroblasts were found. RBC was low. MCV and MCH were extremely high, compared to adult erythrocyte levels. Hemoglobin and hematocrit slightly decreased before weaning. RBC, hemoglobin and hematocrit increased with age and reached adult levels by Day 56. MCV and MCH values decreased, towards adult levels, until weaning. Platelets rapidly increased and reached adult levels before weaning. WBC increased after birth having higher counts in males than in females on Day 35 and thereafter. Glucose, TP and albumin increased with age and reached adult levels by Day 28. ALP was high in fetuses and changed with age having two peaks similar to those reported in man. Cholesterols gradually increased after birth and had a peak on Day 14. Urea nitrogen, inorganic phosphorus and calcium were slightly high in fetuses and preweaned offspring. Potassium was high in fetuses but no age-related trends were seen in offspring.
在妊娠晚期、哺乳期和断奶后，对斯普拉格-道利大鼠的母鼠及其后代的血液学和血清生化指标进行了测量。在母鼠中，产后红细胞参数略低、血小板计数高、中性粒细胞频率高，尽管白细胞无明显变化。在妊娠第20天，葡萄糖和甘油三酯极高，总蛋白和白蛋白较低。这些变化可能归因于妊娠或分娩。在妊娠第20天的胎儿和出生后的后代中，红细胞出现大小不均、多染性、嗜碱性点彩和豪-焦小体，且发现有幼红细胞。红细胞计数低。与成年红细胞水平相比，平均红细胞体积和平均红细胞血红蛋白含量极高。血红蛋白和血细胞比容在断奶前略有下降。红细胞计数、血红蛋白和血细胞比容随年龄增加，到第56天达到成年水平。平均红细胞体积和平均红细胞血红蛋白含量值在断奶前逐渐降至成年水平。血小板迅速增加，在断奶前达到成年水平。出生后白细胞增加，在第35天及之后雄性白细胞计数高于雌性。葡萄糖、总蛋白和白蛋白随年龄增加，到第28天达到成年水平。碱性磷酸酶在胎儿中较高，并随年龄变化，有两个与人类报道相似的峰值。胆固醇在出生后逐渐增加，在第14天达到峰值。尿素氮、无机磷和钙在胎儿和断奶前的后代中略高。胎儿中钾含量高，但后代中未观察到与年龄相关的趋势。
