Campbell Stephanie, Marriott Michael, Nahmias Claude, MacQueen Glenda M
Mood Disorders Program and Department of Radiology, McMaster University, Hamilton, Ontario, Canada.
Am J Psychiatry. 2004 Apr;161(4):598-607. doi: 10.1176/appi.ajp.161.4.598.
A number of studies have used magnetic resonance imaging to examine volumetric differences in temporal structures in subjects suffering from major depressive disorder. Studies have reported lower hippocampal and amygdala volume, but results have been inconsistent. The authors were interested, therefore, in examining these studies in the aggregate in order to determine whether hippocampal volume is lower in major depressive disorder. They also examined factors that may contribute to the disparate results in the literature.
A meta-analysis was conducted of studies that used magnetic resonance imaging to assess the volume of the hippocampus and related structures in patients with major depressive disorder.
Patients were seen to have lower hippocampal volume relative to comparison subjects, detectable if the hippocampus was measured as a discrete structure.
Although the effect of major depressive disorder on amygdala volume remains to be conclusively established, inclusion of the amygdala with the hippocampus appears to have decreased the likelihood of detecting volumetric differences in either structure. Slice thickness or other scan parameters did not account for a substantive amount of the variance in results, whereas clinical variables of the populations studied, such as duration of illness or presence of abuse, may account for much of the discrepancy between findings.
多项研究已使用磁共振成像来检查重度抑郁症患者颞叶结构的体积差异。研究报告了海马体和杏仁核体积较小，但结果并不一致。因此，作者有兴趣综合审视这些研究，以确定重度抑郁症患者的海马体体积是否较小。他们还研究了可能导致文献中结果存在差异的因素。
对使用磁共振成像评估重度抑郁症患者海马体及相关结构体积的研究进行荟萃分析。
与对照受试者相比，患者的海马体体积较小，如果将海马体作为一个独立结构进行测量则可检测到这种差异。
虽然重度抑郁症对杏仁核体积的影响仍有待最终确定，但将杏仁核与海马体一起考虑似乎降低了检测任一结构体积差异的可能性。切片厚度或其他扫描参数并不能解释结果中很大一部分差异，而所研究人群的临床变量，如病程或是否存在虐待情况，可能是造成研究结果存在很大差异的主要原因。
