健康与疾病状态下的人类成体海马神经发生

Human adult hippocampal neurogenesis in health and disease.

作者信息

Alonso-Moreno M C, Gallardo-Caballero M, Prádanos-Senén A V, Llorens-Martín M

机构信息

Department of Molecular Neuropathology, Centro de Biología Molecular "Severo Ochoa" (CBMSO), Spanish Research Council (CSIC)-Universidad Autónoma de Madrid (UAM), Madrid, Spain.

Center for Networked Biomedical Research On Neurodegenerative Diseases (CIBERNED), Madrid, Spain.

出版信息

Aging Brain. 2025 Jul 22;8:100145. doi: 10.1016/j.nbas.2025.100145. eCollection 2025.

DOI:10.1016/j.nbas.2025.100145

PMID:40735066

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12304703/

Abstract

The mammalian hippocampus generates new dentate granule cells (DGCs) throughout life. This process, named adult hippocampal neurogenesis (AHN), participates in hippocampal functions such as memory and mood regulation. Moreover, AHN is impaired in mouse models and patients with neurodegenerative and psychiatric disorders. Additionally, physiological aging targets AHN and the integrity of the hippocampal neurogenic niche. This perspective review aims to discuss the regulation of human AHN in patients with neurodegenerative and psychistric conditions. Moreover, we will address key adaptations of human AHN and the neurogenic niche in response to physiological aging.

摘要

哺乳动物的海马体在其一生中都会产生新的齿状颗粒细胞（DGCs）。这一过程被称为成体海马神经发生（AHN），它参与诸如记忆和情绪调节等海马体功能。此外，在神经退行性疾病和精神疾病的小鼠模型及患者中，AHN会受到损害。另外，生理衰老会影响AHN以及海马神经发生微环境的完整性。这篇观点综述旨在探讨神经退行性疾病和精神疾病患者中人类AHN的调节机制。此外，我们还将探讨人类AHN和神经发生微环境对生理衰老的关键适应性变化。