Bushe Chris, Holt Richard
Eli Lilly & Co. Ltd, Basingstoke, University of Southampton, UK.
Br J Psychiatry Suppl. 2004 Apr;47:S67-71. doi: 10.1192/bjp.184.47.s67.
A number of studies have examined the prevalence of diabetes mellitus and impaired glucose tolerance in general populations and in those with schizophrenia and other forms of serious mental illness.
To establish whether it is possible to describe accurately comparative rates of diabetes mellitus and impaired glucose tolerance in populations of people with schizophrenia and those without mental illness.
Review of current literature.
Research published in the pre-neuroleptic era suggested that people with severe mental illness were at increased risk of developing glycaemic abnormalities. Recent studies appear to confirm that the prevalence of diabetes and impaired glucose tolerance may be higher in people with schizophrenia than in the general population, and suggest that patients with schizophrenia have impaired glucose tolerance even before they begin treatment.
Schizophrenia may be a significant and independent risk factor for both diabetes and impaired glucose tolerance. Current data preclude precise estimates of the prevalence of these conditions among people with schizophrenia.
许多研究已调查了普通人群以及精神分裂症患者和其他严重精神疾病患者中糖尿病和糖耐量受损的患病率。
确定是否有可能准确描述精神分裂症患者群体与无精神疾病人群中糖尿病和糖耐量受损的比较发生率。
回顾当前文献。
在使用抗精神病药物之前的时代发表的研究表明，严重精神疾病患者发生血糖异常的风险增加。最近的研究似乎证实，精神分裂症患者中糖尿病和糖耐量受损的患病率可能高于普通人群，并表明精神分裂症患者在开始治疗前就存在糖耐量受损。
精神分裂症可能是糖尿病和糖耐量受损的一个重要且独立的危险因素。目前的数据无法精确估计这些疾病在精神分裂症患者中的患病率。
