Xu Zhiguo, Huang Song, Du Fanglu, Peng Caiyun, Tian Yuwang
Hunan College of TCM, Changsha 410004.
Zhong Yao Cai. 2003 Dec;26(12):867-9.
To find the active constituents of Rosa bracteata Wendl. to antagonize withdrawal syndrome in morphinedependent mice.
The constituents were isolated and purified by silica gel chromatography repeatedly. Their structures were made clear by chemical reactions and on the evidence of spectroscopy.
Five compounds were isolated from the fruits and four of them were determined as trimethly citrate, dimethyl 3-carboxyl-3-hydroxypentanedioate, 3-hydroxy-3-methoxycarbonyl-pentanedioic acid, calcium citrate, which were found from the Rose genus plant for the first time.
寻找针刺拮抗吗啡依赖小鼠戒断症状的有效部位。
采用反复硅胶柱色谱法分离纯化各部位化学成分，通过化学反应和波谱分析鉴定其结构。
从果实中分离得到5个化合物，其中4个鉴定为柠檬酸三甲酯、3-羧基-3-羟基戊二酸二甲酯、3-羟基-3-甲氧羰基戊二酸、柠檬酸钙，均为首次从蔷薇属植物中分得。
