Moya Jacqueline, Bearer Cynthia F, Etzel Ruth A
US Environmental Protection Agency, National Center for Environmental Assessment, Office of Research and Development, Washington, DC 20460, USA.
Pediatrics. 2004 Apr;113(4 Suppl):996-1006.
Infant, child, and adolescent exposures to environmental toxicants are different from those of adults because of differences in behavior and physiology. Because of these differences, there is the potential for quantitatively different exposures at various stages of development. Pediatricians are well aware of these behavioral and physiologic differences from a clinical standpoint--namely, food and water intake, soil ingestion, mouthing behavior, inhalation physiology, and activity level--as they relate to the ratio of these parameters between the adult and the child when considering weight and surface area. Pediatricians recognized the importance of pica as a cause of lead poisoning, the noxious effect of second-hand smoke, and the greater propensity for addiction during the adolescent years. For determining the differences in impact of many environmental toxicants between adults and children, research is needed to document where and whether these differences result in deleterious effects.
由于行为和生理方面的差异,婴儿、儿童和青少年接触环境毒物的情况与成年人不同。由于这些差异,在发育的各个阶段存在定量上不同的接触可能性。从临床角度来看,儿科医生非常清楚这些行为和生理差异,即食物和水的摄入量、土壤摄入量、口含行为、吸入生理以及活动水平,因为在考虑体重和表面积时,这些参数在成人和儿童之间的比例有所不同。儿科医生认识到异食癖作为铅中毒原因的重要性、二手烟的有害影响以及青少年时期更大的成瘾倾向。为了确定成人和儿童在许多环境毒物影响方面的差异,需要进行研究来记录这些差异在哪里以及是否会导致有害影响。