Singhal K C, Sharma S, Mehta B K
Department of Pharmacology, JN Medical College, Aligarh Muslim University, India.
Indian J Exp Biol. 1992 Jun;30(6):546-8.
Effect of aqueous and alcoholic extract of C. anthelminticum was studied on the spontaneous movements of the whole worm and nerve-muscle preparation of S. cervi. Ethylacetate, acetone and methanol extract showed similar effect, of causing inhibition of spontaneous motility of the nerve-muscle preparation of S. cervi characterized by decreased amplitude and frequency of contractions. The inhibitory effect on the motility was reversible. Further, the extracts did not involve the blockade of cholinergic receptors as evidenced by the presence of unaltered stimulant response of acetylcholine in the presence of drug in bathing fluid.
研究了驱虫豆蔻水提取物和醇提取物对鹿鞭虫全虫及神经肌肉标本自发运动的影响。乙酸乙酯、丙酮和甲醇提取物显示出相似的效果，即抑制鹿鞭虫神经肌肉标本的自发运动，其特征为收缩幅度和频率降低。对运动的抑制作用是可逆的。此外，提取物并不涉及胆碱能受体的阻断，这一点可通过在浴液中存在药物时乙酰胆碱的刺激反应未改变得到证明。
