Canale Andrea, Lacilla Michelangelo, Giordano Carlo, De Sanctis Alice, Albera Roberto
Department of Medico-Surgical Sciences, Section of Audiology, University of Turin, Turin, Italy.
Eur Arch Otorhinolaryngol. 2005 Mar;262(3):208-12. doi: 10.1007/s00405-004-0739-7. Epub 2004 Apr 2.
Low frequency sudden hearing loss (LFSHL) is a frequent finding in the otological practice. Several prognostic indicators have been suggested concerning the prediction of the outcome of sudden hearing loss, but so far there are no proven factors to establish the prognosis. The aim of this study was to assess whether OAEs could be considered as a reliable prognostic test in LFSHL. The study group consisted of 20 patients presenting with a unilateral LFSHL. Each patient was submitted to spontaneous otoacoustic emissions (SOAEs), transient otoacoustic emissions (TEOAEs) and distortion products (DPOAEs) recording and then treated with glycerol administrated intravenously in 3-h intervals for 4 days. Pure tone audiometry (PTA) threshold was evaluated again 1 h after the last administration of glycerol. After osmotic therapy 12 patients (60%) showed a significant PTA improvement with a mean improvement of 11 dB; modifications were significant at the Student's t test for paired data (P<0.0001). The relationship between the pretherapy presence or absence of SOAEs, TEOAEs and DPOAEs and PTA modification was not significant at the exact Fisher's test. In conclusion, even if our study supports that OAEs could be an indicator of the inner ear functional state, they cannot be utilized as a prognostic test in LFSHL in relation to the efficacy of osmotic therapy. Among the other parameters evaluated, only the precocity of therapy seems to be related to prognosis in LFSHL.
低频突发性听力损失（LFSHL）是耳科临床中常见的病症。关于突发性听力损失的预后预测，已经提出了几种预后指标，但到目前为止，尚无经证实的因素可用于确定预后。本研究的目的是评估耳声发射（OAEs）是否可被视为LFSHL的可靠预后检测方法。研究组由20例单侧LFSHL患者组成。每位患者均接受了自发性耳声发射（SOAEs）、瞬态耳声发射（TEOAEs）和畸变产物耳声发射（DPOAEs）记录，然后以3小时的间隔静脉注射甘油，持续4天。在最后一次注射甘油1小时后，再次评估纯音听力测定（PTA）阈值。渗透疗法后，12例患者（60%）的PTA有显著改善，平均改善11dB；在配对数据的Student t检验中，差异具有统计学意义（P<0.0001）。在精确的Fisher检验中，治疗前SOAEs、TEOAEs和DPOAEs的有无与PTA改善之间的关系不显著。总之，即使我们的研究支持OAEs可能是内耳功能状态的一个指标，但就渗透疗法的疗效而言，它们不能用作LFSHL的预后检测方法。在评估的其他参数中，似乎只有治疗的及时性与LFSHL的预后有关。
