Rani M A, Andrade C, David J
Department of Pharmacology, St. John's Medical College, Bangalore.
Indian J Physiol Pharmacol. 1992 Apr;36(2):93-6.
In alloxan-diabetic rats of 4 wk duration with blood glucose levels of about 300 mg/100 ml, the tail flick reaction time (TFRT) to thermal stimuli was significantly elevated (P less than 0.25), indicating hypoalgesia. Intraperitoneal dothiepin, injections of 25 mg & 50 mg/kg body weight per day did not significantly alter the TFRT, either in control or in diabetic rats, following either acute (one dose), or short term (once a day for five days) administration. It is concluded that at least in the dosage schedule used herein, dothiepin does not influence hypoalgesia of diabetic neuropathy.
在病程为4周、血糖水平约为300mg/100ml的四氧嘧啶糖尿病大鼠中，对热刺激的甩尾反应时间（TFRT）显著延长（P小于0.25），表明存在痛觉减退。腹腔注射多塞平，每天25mg及50mg/kg体重，无论是急性给药（一剂）还是短期给药（每天一次，共五天），对正常大鼠或糖尿病大鼠的TFRT均无显著影响。得出的结论是，至少在本文所用的给药方案中，多塞平不影响糖尿病性神经病变的痛觉减退。
