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英国一个高度工业化地区的职业性哮喘:来自当地监测计划的报告。

Occupational asthma in a highly industrialized region of UK: report from a local surveillance scheme.

作者信息

Di Stefano Fabio, Siriruttanapruk Somkiat, McCoach Jennifer, Di Gioacchino Mario, Burge Peter Sherwood

机构信息

Allergy and Clinical Immunology Department, University G. d'Annunzio, Chieti, Italy.

出版信息

Eur Ann Allergy Clin Immunol. 2004 Feb;36(2):56-62.

Abstract

Estimates of the incidence of occupational asthma may be derived from surveillance schemes established in several countries. SHIELD is a voluntary surveillance scheme for occupational asthma in the West Midlands, a highly industrialized region of UK. The aim of this study was to estimate the general and specific incidence of occupational asthma in the West Midlands in 1990-97. The annual incidence was 41.2/million. There was a two fold difference in the incidence by sex (male 59.6/million/yr; female 27.4/million/yr). The highest annual incidence (53.2/million) was observed in the age group 45-64 yr (male) and 45-59 yr (female). Spray painters were the occupation at the highest risk of developing occupational asthma, followed by electroplaters, rubber and plastic workers, bakery workers and moulders. Although the percentage of reported cases was low among healthcare workers, there was a raising trend. Isocyanates still remained the most common causative agents with 190 (17.3%) out of the total 1097 cases reported to the surveillance scheme in seven years. There was a decrease in the reported cases due to colophony (9.5% to 4.6%), flour & wheat (8.9% to 4.9%). There was an increase of reported cases due to latex (0.4% to 4.9%) and glutaraldehyde (1.3% to 5.6%). The serial mesurement of peak expiratory flow at and away from work was the most used method of diagnosis to confirm the occupational cause of asthma. Specific bronchial challenge test with the occupational agents were used when the serial measurement of peak expiratory flow was not able to confirm undoubtdely the diagnostic suspicion or when it was difficult to identify the possible causative agent due to multiple exposures in the workplace. Following diagnosis, 24% of the patients were moved away from exposure within the same workplace in 1997, compared to 15.8% in the previous years. Those remaining exposed to the causative agent in the same workplace decreased from 28.3% to 17.7% between 1990-97. The surveillance of occupational asthma trough this voluntary scheme has allowed to monitor the incidence of the disease in the region and to identify clusters of cases, where control measures are a priority.

摘要

职业性哮喘发病率的估计值可从多个国家建立的监测计划中得出。SHIELD是英国高度工业化地区西米德兰兹郡的一项职业性哮喘自愿监测计划。本研究的目的是估计1990 - 1997年西米德兰兹郡职业性哮喘的总体发病率和特定发病率。年发病率为41.2/百万。发病率在性别上有两倍差异(男性59.6/百万/年;女性27.4/百万/年)。45 - 64岁男性和45 - 59岁女性的年发病率最高(53.2/百万)。喷漆工是患职业性哮喘风险最高的职业,其次是电镀工、橡胶和塑料工人、面包师和铸工。尽管医护人员中报告病例的比例较低,但呈上升趋势。异氰酸酯仍然是最常见的致病因素,在七年内向监测计划报告的1097例病例中,有190例(17.3%)由其导致。因松香(从9.5%降至4.6%)、面粉和小麦(从8.9%降至4.9%)导致的报告病例有所减少。因乳胶(从0.4%增至4.9%)和戊二醛(从1.3%增至5.6%)导致的报告病例有所增加。在工作时和工作外连续测量呼气峰值流速是确诊职业性哮喘病因最常用的诊断方法。当连续测量呼气峰值流速无法明确确诊怀疑或因工作场所多次接触难以确定可能的致病因素时,会使用针对职业性致病因素的特异性支气管激发试验。确诊后,1997年24%的患者在同一工作场所被调离接触源,而前几年为15.8%。1990 - 1997年期间,在同一工作场所仍接触致病因素的患者比例从28.3%降至17.7%。通过这一自愿计划对职业性哮喘进行监测,能够对该地区疾病的发病率进行监测,并识别病例聚集区,在这些区域控制措施是优先事项。

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