Dhuley Jayant N
Pharmacology and Toxicology Section, Research and Development Division, Hindustan Antibiotics Ltd., Pimpri, Pune 411 018, India.
Hindustan Antibiot Bull. 2002 Feb-Nov;44(1-4):53-9.
Rhinax, a polyherbal formulation, exhibited hepatoprotective function when tested against antitubercular drug-induced hepatotoxicity in rats. Suppression of GSH and antioxidant enzymes "superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), gultathionle peroxidase (GPx) and glutathione S-transferase (GST) were noticed in the liver of antitubercular chemotherapeutic agents (namely isoniazid, rifampicin and pyrazinamide) treated animals accompanied with an increase in cytochrome P-450 contents and increased production of lipid peroxidation. Rhinax afforded hepatoprotection by inhibiting lipid peroxidation and, as a result, the animals showed improved antioxidant status.
Rhinax是一种多草药配方，在针对大鼠抗结核药物诱导的肝毒性进行测试时，表现出肝脏保护功能。在接受抗结核化疗药物（即异烟肼、利福平和平吡嗪酰胺）治疗的动物肝脏中，观察到谷胱甘肽（GSH）和抗氧化酶“超氧化物歧化酶（SOD）、过氧化氢酶（CAT）、谷胱甘肽还原酶（GR）、谷胱甘肽过氧化物酶（GPx）和谷胱甘肽S-转移酶（GST）”受到抑制，同时细胞色素P-450含量增加，脂质过氧化产物增多。Rhinax通过抑制脂质过氧化提供肝脏保护，结果，动物的抗氧化状态得到改善。
