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实体器官移植、免疫抑制与皮肤癌之间的历史关联。

The historical link between solid-organ transplantation, immunosuppression, and skin cancer.

作者信息

Randle Henry W

机构信息

Department of Dermatology, Mayo Clinic, Jacksonville, Florida 32224, USA.

出版信息

Dermatol Surg. 2004 Apr;30(4 Pt 2):595-7. doi: 10.1111/j.1524-4725.2004.30142.x.

DOI:10.1111/j.1524-4725.2004.30142.x
PMID:15061841
Abstract

BACKGROUND

Skin cancers are more common in organ transplant recipients than in the general population.

OBJECTIVE

The objective of this study was establish the historical link between organ transplantation, immunosuppression, and the development of skin cancer.

METHODS

The pertinent literature in cutaneous oncology and transplantation is reviewed.

RESULTS

There is a historical link between organ transplants, immunosuppression, and the subsequent development of skin cancers.

CONCLUSIONS

Organ transplant recipients have more skin cancer than those in the general population and this is temporally related to their degree of immunosuppression.

摘要

背景

皮肤癌在器官移植受者中比在普通人群中更常见。

目的

本研究的目的是建立器官移植、免疫抑制与皮肤癌发生之间的历史联系。

方法

回顾了皮肤肿瘤学和移植领域的相关文献。

结果

器官移植、免疫抑制与随后皮肤癌的发生之间存在历史联系。

结论

器官移植受者患皮肤癌的几率高于普通人群,且这在时间上与他们的免疫抑制程度相关。

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1
The historical link between solid-organ transplantation, immunosuppression, and skin cancer.实体器官移植、免疫抑制与皮肤癌之间的历史关联。
Dermatol Surg. 2004 Apr;30(4 Pt 2):595-7. doi: 10.1111/j.1524-4725.2004.30142.x.
2
Reduction of immunosuppression for transplant-associated skin cancer: expert consensus survey.
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Comparative epidemiology and pathogenic factors for nonmelanoma skin cancer in organ transplant patients.器官移植患者非黑色素瘤皮肤癌的比较流行病学及致病因素
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Skin lesions in adult liver transplant recipients: a study of 100 consecutive patients.成年肝移植受者的皮肤病变:对100例连续患者的研究。
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Management of skin cancer in solid organ transplant recipients.实体器官移植受者皮肤癌的管理。
Dermatol Ther. 2005 Jan-Feb;18(1):12-8. doi: 10.1111/j.1529-8019.2005.05002.x.
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Organ transplantation and skin cancer: basic problems and new perspectives.器官移植与皮肤癌:基本问题与新视角。
Exp Dermatol. 2010 Jun;19(6):473-82. doi: 10.1111/j.1600-0625.2010.01086.x. Epub 2010 May 7.
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The role of the transplant physician in the management of skin cancers after organ transplantation.移植医生在器官移植后皮肤癌管理中的作用。
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[Cutaneous complications after organ transplantation].[器官移植后的皮肤并发症]
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Reduction of immunosuppression for transplant-associated skin cancer: thresholds and risks.降低移植相关皮肤癌的免疫抑制:阈值与风险
Br J Dermatol. 2007 Dec;157(6):1183-8. doi: 10.1111/j.1365-2133.2007.08203.x. Epub 2007 Oct 4.
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Management of skin cancer after organ transplantation.器官移植后皮肤癌的管理。
G Ital Dermatol Venereol. 2011 Oct;146(5):341-52.

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J Nephrol. 2016 Oct;29(5):703-9. doi: 10.1007/s40620-015-0237-6. Epub 2015 Oct 10.
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Regression of advanced melanoma upon withdrawal of immunosuppression: case series and literature review.免疫抑制治疗停药后晚期黑色素瘤消退:病例系列及文献复习。
Med Oncol. 2010 Dec;27(4):1127-32. doi: 10.1007/s12032-009-9348-z. Epub 2009 Nov 5.
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Mitochondrion. 2010 Mar;10(2):94-101. doi: 10.1016/j.mito.2009.10.001. Epub 2009 Oct 31.
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Cutaneous malignancies among HIV-infected persons.HIV感染者中的皮肤恶性肿瘤。
Arch Intern Med. 2009 Jun 22;169(12):1130-8. doi: 10.1001/archinternmed.2009.104.