疱疹性眼病：免疫发病机制与治疗措施

Herpetic eye disease: immunopathogenesis and therapeutic measures.

作者信息

Deshpande Shilpa, Banerjee Kaustuv, Biswas Partha Sarathi, Rouse Barry T

机构信息

Department of Microbiology, M 409, Walters Life Sciences Bldg, 1414 Cumberland Avenue, College of Arts and Sciences, University of Tennessee, Knoxville, TN 37996, USA.

出版信息

Expert Rev Mol Med. 2004 Mar 30;6(8):1-14. doi: 10.1017/S1462399404007604.

DOI:10.1017/S1462399404007604

PMID:15061872

Abstract

Infection of the cornea with herpes simplex virus (HSV) can result in a chronic disease called herpetic stromal keratitis (HSK). The disease represents one of the leading causes of infectious blindness in the Western world. Immune-mediated cellular damage is suspected in the pathogenesis of human HSK. The murine model has been pivotal in further establishing HSK as an immunopathological disease. This article reviews understanding of HSK, both in humans and in the mouse model, with an emphasis on possible future therapeutic strategies to counteract this blinding immunoinflammatory disease.

摘要

单纯疱疹病毒（HSV）感染角膜可导致一种名为疱疹性基质性角膜炎（HSK）的慢性疾病。该疾病是西方世界感染性失明的主要原因之一。人类HSK的发病机制疑似存在免疫介导的细胞损伤。小鼠模型在进一步确定HSK为免疫病理疾病方面发挥了关键作用。本文综述了对人类和小鼠模型中HSK的认识，重点关注未来对抗这种致盲免疫炎症性疾病的可能治疗策略。