Kaufman Bruce A
Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI 53201, USA.
Pediatr Clin North Am. 2004 Apr;51(2):389-419. doi: 10.1016/S0031-3955(03)00207-4.
Defects of development of the neural tube can result in a number of seemingly different malformations. Understanding the abnormal embryology helps one understand the malformations and their surgical treatments. The clinical presentations and the follow-up of these patients require attention to various end organs besides the nervous system. For most of these conditions, long-term follow-up is necessary regardless of initial treatment. A decline in function is not a part of the natural history of these malformations and requires prompt evaluation and treatment.
神经管发育缺陷可导致许多看似不同的畸形。了解异常胚胎学有助于理解这些畸形及其手术治疗方法。这些患者的临床表现和随访除了关注神经系统外，还需要关注各种终末器官。对于大多数这些情况，无论初始治疗如何，长期随访都是必要的。功能下降并非这些畸形自然病程的一部分，需要及时评估和治疗。
