Osuga T, Obata T, Ikehira H
Research Center for Frontier Medical Engineering, Chiba University, Yayoi, Inage, Chiba, Japan.
Magn Reson Imaging. 2004 Apr;22(3):413-6. doi: 10.1016/j.mri.2003.07.003.
Observations using MRI were performed for the motion of heavy water injected into a hollow fiber dialyzer. A cylindrical dialyzer houses a bundle of 10,000 hollow fibers. Because blood components permeate through the hollow fiber membrane from the interior to the exterior of the hollow fiber, which is the dialysate flow path, uniformity of dialysate flow is required. The dialyzer was initially filled with saline and heavy water was injected into the inlet port of the dialysate flow path. MRI tuned for protons could distinguish the injected heavy water from the already present saline. Due to the specific gravity difference, MRI could observe the sedimentation of the injected heavy water flowing beneath the already present saline. The uniformity of the dialysate flow was supported by the finding that the injected heavy water brought about uniform sedimentation and distributed the already present saline uniformly throughout the entire volume of the dialyzer.
使用磁共振成像（MRI）对注入中空纤维透析器的重水运动进行了观察。一个圆柱形透析器容纳一束10000根中空纤维。由于血液成分从中空纤维内部渗透到中空纤维外部（即透析液流动路径），所以需要透析液流动均匀。透析器最初充满盐水，然后将重水注入透析液流动路径的入口。调谐到质子的MRI能够将注入的重水与已存在的盐水区分开来。由于比重差异，MRI可以观察到注入的重水在已存在的盐水下方的沉降情况。注入的重水带来均匀沉降，并将已存在的盐水均匀分布在透析器的整个体积中，这一发现支持了透析液流动的均匀性。
