Anderson J R, Ackerman J J H, Garbow J R
Department of Chemistry, Washington University, 1 Brookings Drive, St. Louis, MO 63130.
Department of Chemistry, Washington University, 1 Brookings Drive, St. Louis, MO 63130 ; Department of Radiology, Washington University, 1 Brookings Drive, St. Louis, MO 63130 ; Department of Internal Medicine, Washington University, 1 Brookings Drive, St. Louis, MO 63130.
Concepts Magn Reson Part B Magn Reson Eng. 2011 Aug;39B(3):149-158. doi: 10.1002/cmr.b.20202.
Two semipermeable, hollow fiber phantoms for the validation of perfusion-sensitive magnetic resonance methods and signal models are described. Semipermeable hollow fibers harvested from a standard commercial hemodialysis cartridge serve to mimic tissue capillary function. Flow of aqueous media through the fiber lumen is achieved with a laboratory-grade peristaltic pump. Diffusion of water and solute species (e.g., Gd-based contrast agent) occurs across the fiber wall, allowing exchange between the lumen and the extralumenal space. Phantom design attributes include: i) small physical size, ii) easy and low-cost construction, iii) definable compartment volumes, and iv) experimental control over media content and flow rate.
描述了两种用于灌注敏感磁共振方法和信号模型验证的半透性中空纤维模型。从标准商用血液透析盒中获取的半透性中空纤维用于模拟组织毛细血管功能。使用实验室级蠕动泵实现水性介质在纤维管腔内的流动。水和溶质种类（例如基于钆的造影剂）在纤维壁上发生扩散，从而允许管腔与管腔外空间之间进行交换。模型设计属性包括：i）物理尺寸小，ii）构建容易且成本低，iii）可定义的隔室体积，以及iv）对介质含量和流速的实验控制。
