Hu Jiani, Xu YingBiao, Jiang Quan, Sehgal Vivek, Shen Yimin, Xuan Yang, Xia Yang
Department of Radiology, Wayne State University, Detroit, MI 48201, USA.
Magn Reson Imaging. 2004 Apr;22(3):427-9. doi: 10.1016/j.mri.2004.01.005.
Fatigue and impairment mobility are frequent problems in multiple sclerosis (MS). Despite its enormous potential, in vivo (1)H MRS of skeletal muscles for MS patients is a largely unexplored field. One fundamental question remains unanswered: whether MS can cause observable proton metabolite changes. High quality two-dimensional in vivo (1)H MRS reveals that the spectral pattern of total creatine (tCr) and trimethyl ammonium (TMA) of soleus muscles of MS patients can be distinctively different from that of healthy volunteers, and in vivo (1)H MRS of skeletal muscles has a potential to become a useful tool in MS study.
疲劳和行动能力受损是多发性硬化症（MS）中常见的问题。尽管具有巨大潜力，但用于MS患者的骨骼肌活体（1）H磁共振波谱（MRS）在很大程度上仍是一个未被探索的领域。一个基本问题仍未得到解答：MS是否会导致可观察到的质子代谢物变化。高质量的二维活体（1）H MRS显示，MS患者比目鱼肌的总肌酸（tCr）和三甲铵（TMA）的光谱模式可能与健康志愿者明显不同，并且骨骼肌的活体（1）H MRS有潜力成为MS研究中的一种有用工具。
