Hu Jiani, Xia Yang, Shen Yimin, Li Jun, Zuo Chun S, Xuan Yang, Jiang Quan
Department of Radiology, Wayne State University, Detroit, Michigan, USA.
J Magn Reson Imaging. 2004 May;19(5):617-22. doi: 10.1002/jmri.20036.
To study the apparent heterogeneous characteristics of trimethyl ammonium (TMA) in healthy human muscles at rest, and to illustrate the importance of establishing the baseline characteristics of proton metabolites in muscles with a West Nile patient.
Point-resolved spectroscopy (PRESS) magnetic resonance spectroscopy imaging (MRSI) with lipid suppression and optional outer-volume presaturation were used to acquire 1H spectra of human muscles at rest at 1.5 Tesla. A total of 28 subjects (27 normal volunteers and 1 patient with West Nile disease) between the ages of 22 and 76 participated in the study.
The apparent T2 values of TMA for soleus and gastrocnemius muscles in normal volunteers are 180 +/- 50 and 80 +/- 20 msec, respectively. This difference has profound effects on the apparent spectral pattern of 1H metabolites. The TMA/total creatine (tCr) spectral pattern of the soleus muscle of a West Nile patient resembles that of gastrocnemius muscle of healthy volunteers.
There are significant differences in the apparent T2 values of TMA between healthy soleus and gastrocnemius muscles at rest. It is important to establish the baseline characteristics of proton metabolites before clinical or physiological studies can be performed.
研究静息状态下健康人体肌肉中三甲铵（TMA）明显的异质性特征，并阐明为一名西尼罗河患者建立肌肉中质子代谢物基线特征的重要性。
采用具有脂质抑制和可选外容积预饱和的点分辨光谱（PRESS）磁共振波谱成像（MRSI），在1.5特斯拉下采集静息状态下人体肌肉的1H谱。共有28名年龄在22至76岁之间的受试者（27名正常志愿者和1名西尼罗河病患者）参与了该研究。
正常志愿者比目鱼肌和腓肠肌中TMA的表观T2值分别为180±50和80±20毫秒。这种差异对1H代谢物的表观光谱模式有深远影响。一名西尼罗河患者比目鱼肌的TMA/总肌酸（tCr）光谱模式类似于健康志愿者腓肠肌的光谱模式。
静息状态下，健康比目鱼肌和腓肠肌中TMA的表观T2值存在显著差异。在进行临床或生理研究之前，建立质子代谢物的基线特征很重要。
