Scalarone G M, Mikami Y, Kurita N, Yazawa K, Miyaji M
Department of Biological Sciences, Idaho State University, Pocatello 83209.
J Antimicrob Chemother. 1992 Feb;29(2):129-36. doi: 10.1093/jac/29.2.129.
The in-vitro postantifungal effect (PAFE) of 5-fluorocytosine for Candida albicans for short periods of time was investigated. Yeast cells were exposed for 0.5, 1 or 2 h to a range of concentrations (0.1-3.2 mg/L) of 5-fluorocytosine. The PAFE was quantitated by determinations of the number of colony forming units at hourly intervals (0-10 h) after removal of the drug by dilution. The length of the PAFE was dependent upon the concentration of 5-fluorocytosine and the duration of exposure. An exposure time of 0.5 h resulted in PAFE's ranging from 0 to 4.2 h. Exposure times of 1 and 2 h resulted in longer PAFEs and in many instances suppression of cell growth was seen for the entire evaluation period (up to ten hours).
研究了5-氟胞嘧啶对白色念珠菌短时间的体外抗真菌后效应（PAFE）。将酵母细胞暴露于一系列浓度（0.1 - 3.2毫克/升）的5-氟胞嘧啶中0.5、1或2小时。通过在药物稀释去除后每隔一小时（0 - 10小时）测定菌落形成单位的数量来定量PAFE。PAFE的时长取决于5-氟胞嘧啶的浓度和暴露持续时间。0.5小时的暴露时间导致PAFE范围为0至4.2小时。1小时和2小时的暴露时间导致更长的PAFE，并且在许多情况下，在整个评估期（长达十小时）内都观察到细胞生长受到抑制。
