红霉素对兔气道上皮细胞体外纤毛运动的影响。

Effect of erythromycin on ciliary motility in rabbit airway epithelium in vitro.

作者信息

Tamaoki J, Chiyotani A, Sakai N, Takeyama K, Takizawa T

机构信息

First Department of Medicine, Tokyo Women's Medical College, Japan.

出版信息

J Antimicrob Chemother. 1992 Feb;29(2):173-8. doi: 10.1093/jac/29.2.173.

DOI:10.1093/jac/29.2.173

PMID:1506333

Abstract

The effect of erythromycin on ciliary beat frequency (CBF) of rabbit tracheal epithelium was studied by a microphoto-oscillation technique in vitro. Addition of erythromycin dose-dependently increased CBF, the maximal increase from the baseline value and EC50 being 23.3 +/- 4.5% (P less than 0.001) and 6.8 +/- 0.9 mg/L, respectively. This effect was not influenced by autonomic receptor antagonists, blockers of arachidonic acid metabolism, Ca(2+)-free medium, or inhibition of protein kinase C and protein kinase A activities.

摘要

采用体外显微光振荡技术研究了红霉素对兔气管上皮细胞纤毛摆动频率（CBF）的影响。加入红霉素后，CBF呈剂量依赖性增加，相对于基线值的最大增加幅度和半数有效浓度（EC50）分别为23.3±4.5%（P<0.001）和6.8±0.9mg/L。自主神经受体拮抗剂、花生四烯酸代谢阻滞剂、无钙培养基或蛋白激酶C和蛋白激酶A活性的抑制均不影响这一效应。