Guttman David S
Department of Botany, University of Toronto, 25 Willcocks St., Toronto, ON, Canada M5S 3B2.
Biotechnol Adv. 2004 May;22(5):363-82. doi: 10.1016/j.biotechadv.2003.11.001.
There are many common disease mechanisms used by bacterial pathogens of plants and humans. They use common means of attachment, secretion and genetic regulation. They share many virulence factors, such as extracellular polysaccharides and some type III secreted effectors. Plant and human innate immune systems also share many similarities. Many of these shared bacterial virulence mechanisms are homologous, but even more appear to have independently converged on a common function. This combination of homologous and analogous systems reveals conserved and critical steps in the disease process. Given these similarities, and the many experimental advantages of plant biology, including ease of replication, stringent genetic and reproductive control, and high throughput with low cost, it is proposed that plants would make excellent models for the study of human pathogenesis.
植物和人类的细菌病原体有许多共同的致病机制。它们采用共同的附着、分泌和基因调控方式。它们共享许多毒力因子，如胞外多糖和一些III型分泌效应子。植物和人类的固有免疫系统也有许多相似之处。这些共享的细菌致病机制中有许多是同源的，但更多的似乎是独立地趋向于共同的功能。同源和类似系统的这种组合揭示了疾病过程中保守且关键的步骤。鉴于这些相似性，以及植物生物学的诸多实验优势，包括易于复制、严格的遗传和生殖控制以及低成本的高通量，有人提出植物将成为研究人类发病机制的优秀模型。
