Staskawicz B J, Mudgett M B, Dangl J L, Galan J E
Department of Plant and Microbial Biology, University of California at Berkeley, Berkeley, CA 94720, USA.
Science. 2001 Jun 22;292(5525):2285-9. doi: 10.1126/science.1062013.
Recent studies in bacterial pathogenesis reveal common and contrasting mechanisms of pathogen virulence and host resistance in plant and animal diseases. This review presents recent developments in the study of plant and animal pathogenesis, with respect to bacterial colonization and the delivery of effector proteins to the host. Furthermore, host defense responses in both plants and animals are discussed in relation to mechanisms of pathogen recognition and defense signaling. Future studies will greatly add to our understanding of the molecular events defining host-pathogen interactions.
近期关于细菌致病机制的研究揭示了植物和动物疾病中病原体毒力和宿主抗性的共同及不同机制。本综述介绍了植物和动物致病机制研究的最新进展，涉及细菌定殖以及效应蛋白向宿主的传递。此外，还讨论了植物和动物的宿主防御反应与病原体识别和防御信号传导机制的关系。未来的研究将极大地增进我们对定义宿主-病原体相互作用的分子事件的理解。
