Terán-García Margarita, Després Jean-Pierre, Couillard Charles, Tremblay Angelo, Bouchard Claude
Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808, USA.
Atherosclerosis. 2004 Apr;173(2):277-83. doi: 10.1016/j.atherosclerosis.2003.12.016.
Twelve pairs of male monozygotic (MZ) twins (mean age +/- S.D.: 21 +/- 2 years) were subjected to an overfeeding protocol of 4.2 MJ (1000 kcal) above their pre-established individual daily energy needs, 6 days a week, over a period of 100 days. Body weight increased significantly (gain of 8.1 kg, P<0.001), as did fat mass (5.4 kg, P<0.001) after overfeeding. Plasma triacylglycerol (TG) levels significantly increased (P<0.05) without change in plasma cholesterol (CHOL). Plasma very-low-density-lipoprotein (VLDL)-TG, VLDL-Apoprotein (Apo) B, low-density-lipoprotein cholesterol (LDL-C) and LDL-Apo B (P</=0.05) rose, whereas high-density-lipoprotein cholesterol (HDL-C) levels fell (P<0.05) raising the CHOL/HDL-C ratio (20%) (P<0.001). Considerable individual differences occurred in plasma lipoprotein responses to overfeeding. However, these changes were not random; significant within-pair resemblance registered for the response of plasma CHOL, TG, VLDL-TG, VLDL-C, LDL-TG, HDL-C, HDL-Apo A-I, HDL2-C, HDL3-C to overfeeding (0.48</=ri</=0.85). Furthermore, a high within-pair resemblance was found for changes in ratios of CHOL/HDL-C (ri=0.86, P<0.0001) and HDL2-C/HDL3-C (ri=0.69, P<0.01). These results strongly suggest that the response of plasma lipoproteins to chronic energy surplus has a significant genetic component as does the detrimental effect of chronic caloric affluence on CHD risk.
十二对男性同卵双胞胎（平均年龄±标准差：21±2岁）接受了一项过量喂食方案，即每周6天，在100天的时间里，每天摄入比预先确定的个人每日能量需求多4.2兆焦耳（1000千卡）的热量。过量喂食后，体重显著增加（增加了8.1千克，P<0.001），脂肪量也显著增加（5.4千克，P<0.001）。血浆甘油三酯（TG）水平显著升高（P<0.05），而血浆胆固醇（CHOL）无变化。血浆极低密度脂蛋白（VLDL）-TG、VLDL载脂蛋白（Apo）B、低密度脂蛋白胆固醇（LDL-C）和LDL-Apo B（P≤0.05）升高，而高密度脂蛋白胆固醇（HDL-C）水平下降（P<0.05），导致CHOL/HDL-C比值升高（20%）（P<0.001）。血浆脂蛋白对过量喂食的反应存在相当大的个体差异。然而，这些变化并非随机的；血浆CHOL、TG、VLDL-TG、VLDL-C、LDL-TG、HDL-C、HDL-Apo A-I、HDL2-C、HDL3-C对过量喂食的反应在双胞胎对之间存在显著的相似性（0.48≤ri≤0.85）。此外，CHOL/HDL-C比值（ri=0.86，P<0.0001）和HDL2-C/HDL3-C比值（ri=0.69，P<0.01）的变化在双胞胎对之间也有很高的相似性。这些结果有力地表明，血浆脂蛋白对慢性能量过剩的反应具有显著的遗传成分，慢性热量充裕对冠心病风险的有害影响也具有显著的遗传成分。
