D-二聚体在主动脉夹层急诊科评估中的应用
D-dimers in the emergency department evaluation of aortic dissection.
作者信息
Perez Alberto, Abbet Philippe, Drescher Michael J
机构信息
Department of Emergency Medicine, University of Connecticut School of Medicine, Hartford Hospital, 80 Seymour Street, PO Box 5037, Hartford, CT 06102-5037, USA.
出版信息
Acad Emerg Med. 2004 Apr;11(4):397-400. doi: 10.1197/j.aem.2003.10.030.
UNLABELLED
Aortic dissection (AD) is the most common acute aortic condition requiring urgent surgery. AD, if not diagnosed in the emergency department (ED), is frequently fatal. AD is a difficult antemortem diagnosis.
OBJECTIVES
To determine if acute AD is associated with an elevation of fibrin degradation products, D-dimers.
METHODS
This was a retrospective chart review of patients diagnosed as having AD in the ED in whom a D-dimer determination was obtained in the ED, prior to any therapeutic intervention. The study was conducted in an urban Level I trauma center between October 1996 and September 2000. Exclusion criteria were referred patients with known diagnosis of AD. The D-dimer assay used was the semiquantitative latex agglutination assay, with a normal range up to 0.5 micro g/mL.
RESULTS
One hundred fifty-six patients were diagnosed as having AD in the ED. Seven patients had a D-dimer assay during their workup. All seven had a positive test.
CONCLUSIONS
All seven patients with an AD who had D-dimer assays performed in the ED had positive results by latex agglutination.
未标注
主动脉夹层（AD）是最常见的需要紧急手术的急性主动脉疾病。如果在急诊科（ED）未被诊断出来，AD通常是致命的。AD是一种难以在生前做出诊断的疾病。
目的
确定急性AD是否与纤维蛋白降解产物D - 二聚体升高有关。
方法
这是一项对在ED中被诊断为患有AD且在任何治疗干预之前在ED中进行了D - 二聚体测定的患者的回顾性病历审查。该研究于1996年10月至2000年9月在一家城市一级创伤中心进行。排除标准为已知诊断为AD的转诊患者。所使用的D - 二聚体检测方法是半定量乳胶凝集试验，正常范围高达0.5μg/mL。
结果
156名患者在ED中被诊断为患有AD。7名患者在检查期间进行了D - 二聚体检测。所有7名患者检测结果均为阳性。
结论
在ED中进行D - 二聚体检测的所有7名AD患者通过乳胶凝集法检测结果均为阳性。
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