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Detection of telomerase hTERT gene expression and its splice variants by RT-PCR.

作者信息

Keith W Nicol, Hoare Stacey F

机构信息

Cancer Research UK Department of Medical Oncology, University of Glasgow, Cancer Research UK Beaston Laboratories, Glasgow, Scotland, UK.

出版信息

Methods Mol Med. 2004;97:297-309. doi: 10.1385/1-59259-760-2:297.

DOI:10.1385/1-59259-760-2:297
PMID:15064501
Abstract
摘要

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Detection of telomerase hTERT gene expression and its splice variants by RT-PCR.通过逆转录聚合酶链反应（RT-PCR）检测端粒酶hTERT基因表达及其剪接变体。
Methods Mol Med. 2004;97:297-309. doi: 10.1385/1-59259-760-2:297.
2
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Human normal T lymphocytes and lymphoid cell lines do express alternative splicing variants of human telomerase reverse transcriptase (hTERT) mRNA.人类正常T淋巴细胞和淋巴细胞系确实表达人端粒酶逆转录酶（hTERT）mRNA的可变剪接变体。
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没有永生的恶性肿瘤？细胞永生化可能是黑色素瘤进展中的晚期事件。
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