黑人和白人男性前列腺组织中的雄激素受体蛋白表达

Androgen receptor protein expression in prostatic tissues in Black and Caucasian men.

作者信息

Olapade-Olaopa E Oluwabunmi, Muronda Charles A, MacKay E Hugh, Danso Alex P, Sandhu Davinder P, Terry Timothy R, Habib Fouad K

机构信息

Department of Urology, Leicester General Hospital, Leicester, United Kingdom.

出版信息

Prostate. 2004 Jun 1;59(4):460-8. doi: 10.1002/pros.20014.

DOI:10.1002/pros.20014

PMID:15065095

Abstract

BACKGROUND

CaP has a higher incidence and mortality in Black men. We hypothesized that subpopulation differences in AR expression may contribute to this phenomenon.

METHOD

AR immunostaining was compared in epithelium and PES of normal, BPH, and CaP tissues from Black African men and UK Caucasian men.

RESULTS

AR expression was similar in normal prostatic epithelium of both groups, but was higher in BPH and CaP epithelium of Black than Caucasian men (P </= 0.0001). Also, AR expression in PES was higher in Caucasian than Black men in normal/atrophic and benign hyperplastic tissues, but there was a similar significant loss of AR expression in PES of CaP tissues of both groups (normal and BPH stroma versus CaP stroma (P </= 0.0001).

CONCLUSIONS

Variations in AR expression between subpopulations may contribute to the phenotypic differences of prostatic diseases in Black and Caucasian men.

摘要

背景

前列腺癌在黑人男性中的发病率和死亡率更高。我们推测雄激素受体（AR）表达的亚群差异可能导致了这一现象。

方法

比较了来自非洲黑人男性和英国白人男性的正常、良性前列腺增生（BPH）和前列腺癌组织的上皮及前列腺周围组织（PES）中的AR免疫染色情况。

结果

两组正常前列腺上皮中的AR表达相似，但黑人男性BPH和前列腺癌上皮中的AR表达高于白人男性（P≤0.0001）。此外，在正常/萎缩和良性增生组织中，白人男性PES中的AR表达高于黑人男性，但两组前列腺癌组织的PES中AR表达均有类似的显著降低（正常和BPH基质与前列腺癌基质相比，P≤0.0001）。