Schlembach Dietmar
University of Texas Medical Branch, Dept. of Obstetrics and Gynecology, Reproductive Sciences, Galveston, Texas 77555-1062, USA.
Fukushima J Med Sci. 2003 Dec;49(2):69-115.
Pre-eclampsia is still one of the leading causes of maternal and fetal morbidity and mortality. Despite active research for many decades, the etiology of this disorder exclusive to human pregnancy is an enigma. Recent evidence suggests there may be several underlying causes or predispositions leading to endothelial dysfunction and causing the signs of hypertension, proteinuria, and edema--findings that allow us to make the diagnosis of the "syndrome" of pre-eclampsia. It is obvious that a single mechanism responsible for the syndrome pre-eclampsia does not exist. Instead, several mechanisms can act together and even multiply each other. The search for the underlying cause of this disorder and for a clinical marker to predict which women will develop pre-eclampsia is ongoing, with its prevention being the ultimate goal.
子痫前期仍然是孕产妇和胎儿发病及死亡的主要原因之一。尽管经过了数十年的积极研究，但这种仅发生于人类妊娠的疾病的病因仍是个谜。最近的证据表明，可能有几种潜在原因或易患因素导致内皮功能障碍，并引发高血压、蛋白尿和水肿等症状——这些表现使我们能够做出子痫前期“综合征”的诊断。显然，不存在单一的机制导致子痫前期综合征。相反，几种机制可能共同起作用，甚至相互叠加。对该疾病潜在病因以及预测哪些女性会发生子痫前期的临床标志物的研究正在进行中，其最终目标是预防。
