妊娠相关肝脏疾病。
Pregnancy-related liver disorders.
作者信息
Goel Ashish, Jamwal Kapil D, Ramachandran Anup, Balasubramanian Kunissery A, Eapen Chundamannil E
机构信息
Department of Hepatology, Division of Gastrointestinal Sciences, Christian Medical College, Vellore 632004, Tamil Nadu, India.
Department of Wellcome Research Unit, Division of Gastrointestinal Sciences, Christian Medical College, Vellore 632004, Tamil Nadu, India.
出版信息
J Clin Exp Hepatol. 2014 Jun;4(2):151-62. doi: 10.1016/j.jceh.2013.03.220. Epub 2013 Mar 16.
Abstract
Pregnancy-related liver disorders accounted for 8% of all maternal deaths at our center from 1999 to 2011. Of the three pregnancy-related liver disorders (acute fatty liver of pregnancy (AFLP), HELLP (Hemolysis, elevated liver enzymes, low platelets) syndrome and pre-eclamptic liver dysfunction, which can lead to adverse maternal and fetal outcome, AFLP is most typically under - diagnosed. Risk of maternal death can be minimised by timely recognition and early/aggressive multi-specialty management of these conditions. Urgent termination of pregnancy remains the cornerstone of therapy for some of these life threatening disorders, but recent advancements in our understanding help us in better overall management of these patients. This review focuses on various aspects of pregnancy-related liver disorders.
摘要
1999年至2011年期间，在我们中心，与妊娠相关的肝脏疾病占所有孕产妇死亡病例的8%。三种与妊娠相关的肝脏疾病（妊娠急性脂肪肝（AFLP）、HELLP（溶血、肝酶升高、血小板减少）综合征和子痫前期肝功能障碍）均可能导致不良的母婴结局，其中AFLP最常被漏诊。及时识别并对这些病症进行早期/积极的多专科管理，可将孕产妇死亡风险降至最低。紧急终止妊娠仍是治疗其中一些危及生命病症的基石，但我们在认识上的最新进展有助于更好地对这些患者进行全面管理。本综述重点关注与妊娠相关的肝脏疾病的各个方面。
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