Bednov Andrey, Ulyanov Sergey, Cheung Cecil, Yodh Arjun G
University of Texas Medical Branch, Center for Biomedical Engineering, 301 University Boulevard, Galveston, Texas 77555-0100, USA.
J Biomed Opt. 2004 Mar-Apr;9(2):347-52. doi: 10.1117/1.1646171.
Modeling of skin burns has been performed in this study. Autocorrelation functions of intensity fluctuations of scattered light were measured for two-layered turbid media. The first layer served as a model for motionless scatterers (optically inhomogeneous gel film) whereas the second one simulated dynamic light scattering (Brownian motion of intralipid particles in aqueous suspension). This medium was used as a model of skin burns. A theory related quasi-elastic light scattering measurements to cutaneous blood flow was used. The dependencies of statistical properties of Doppler signal on the properties of burned skin as well as on the velocity of cutaneous blood flow have been investigated. Theoretical predictions have been verified by measurements both of dynamic and stationary light scattering in model media.
本研究对皮肤烧伤进行了建模。测量了两层浑浊介质中散射光强度波动的自相关函数。第一层作为静止散射体的模型(光学不均匀凝胶膜),而第二层模拟动态光散射(水悬浮液中脂质体颗粒的布朗运动)。这种介质被用作皮肤烧伤的模型。使用了一种将准弹性光散射测量与皮肤血流相关联的理论。研究了多普勒信号的统计特性与烧伤皮肤特性以及皮肤血流速度之间的相关性。通过对模型介质中动态和静态光散射的测量验证了理论预测。