Kranzler Henry R, Armeli Stephen, Feinn Richard, Tennen Howard
Alcohol Research Center, Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030-2103, USA.
J Consult Clin Psychol. 2004 Apr;72(2):317-27. doi: 10.1037/0022-006X.72.2.317.
One hundred fifty-three problem drinkers were randomly assigned to receive naltrexone 50 mg or placebo on a daily or targeted (to high-risk drinking situations) basis. Using structured nightly diaries, participants recorded negative and positive mood, desire to drink, and alcohol consumption over 8 weeks. Results indicated that individuals engaged in any drinking and heavy drinking more on days characterized by relatively higher levels of positive or negative mood states. Naltrexone attenuated the positive association between heavy drinking and both positive and negative mood, and targeted administration attenuated the positive association between heavy drinking and positive mood. There was also evidence that desire to drink mediated the effect of targeted administration on the relation between positive mood and any drinking that day. These findings underscore the utility of daily measurement for understanding the processes that underlie pharmacological interventions for problem drinking.
153名问题饮酒者被随机分配，每日或在特定情况下（针对高危饮酒情境）服用50毫克纳曲酮或安慰剂。参与者使用结构化的夜间日记记录8周内的负面和正面情绪、饮酒欲望及酒精摄入量。结果表明，在正面或负面情绪水平相对较高的日子里，个体饮酒及大量饮酒的情况更多。纳曲酮减弱了大量饮酒与正面和负面情绪之间的正相关，而特定给药方式减弱了大量饮酒与正面情绪之间的正相关。还有证据表明，饮酒欲望介导了特定给药方式对正面情绪与当日任何饮酒行为之间关系的影响。这些发现强调了每日测量对于理解问题饮酒药物干预背后机制的实用性。
