Carbon Maren, Wübbeler Gerd, Mackert Bruno-Marcel, Mackert Jan, Ramsbacher Josef, Trahms Lutz, Curio Gabriel
Neurophysics Group, Department of Neurology, Charité-University Medicine Berlin, Campus Benjamin Franklin, 12200 Berlin, Germany.
Clin Neurophysiol. 2004 May;115(5):1027-32. doi: 10.1016/j.clinph.2003.12.035.
Injury currents are a hallmark of acute lesions in polarized cells. Our objective was to develop a non-invasive technique for monitoring human near-DC injury currents in vivo.
Using diagnostic muscle biopsy as controlled paradigm, injury-related magnetic DC-fields were mapped for 60 min postsurgery over leg muscle lesions of 9 subjects. A 49-channel magnetometer was used in combination with a mechanical horizontal modulation of the subject beneath the sensor array.
Magnetic DC-field maps showed salient differences between biopsy and contralateral legs in 8/9 patients with a characteristic slowly decaying field in all biopsy legs. A variety of anomalous DC-field patterns was recorded over the biopsy sites, corresponding to theoretically predicted geometric variations of equivalent DC-current dipoles, i.e. wound surfaces, pointing into opposing muscle fibre ends. By contrast, all control measurements showed an elongated dipolar DC-field pattern. Additionally, mean global DC-field strengths were significantly higher over biopsy legs compared to the contralateral site.
Our pilot data illustrate that human injury currents can be detected using non-invasive magnetometry. Thus, DC-magnetometry may provide an essential new tool for clinical monitoring of injury currents, possibly also in brain tissue, e.g. in case of anoxic or peri-infarct depolarizations.
损伤电流是极化细胞急性损伤的一个标志。我们的目标是开发一种用于在体内监测人体近直流损伤电流的非侵入性技术。
以诊断性肌肉活检作为对照范例，在9名受试者腿部肌肉损伤术后60分钟内绘制与损伤相关的直流磁场图。使用一台49通道磁力计，并结合受试者在传感器阵列下方的机械水平移动。
在9名患者中的8名患者中，活检侧腿与对侧腿之间的直流磁场图显示出显著差异，所有活检侧腿均具有特征性的缓慢衰减磁场。在活检部位记录到多种异常的直流磁场模式，这与理论预测的等效直流电流偶极子（即伤口表面）指向相反肌纤维末端的几何变化相对应。相比之下，所有对照测量均显示出拉长的偶极直流磁场模式。此外，活检侧腿的平均整体直流磁场强度显著高于对侧部位。
我们的初步数据表明，使用非侵入性磁力测量法可以检测到人体损伤电流。因此，直流磁力测量法可能为损伤电流的临床监测提供一种重要的新工具，在脑组织中也可能适用，例如在缺氧或梗死周围去极化的情况下。
