Rainka Matthew P, Aye Yimon, Buchwald Stephen L
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):5821-3. doi: 10.1073/pnas.0307764101. Epub 2004 Apr 5.
A chiral copper-hydride catalyst for the asymmetric conjugate reduction of alpha,beta-unsaturated carbonyl compounds has been used for the reduction of substrates containing beta-nitrogen substituents. A new set of reaction conditions has allowed for a variety of beta-azaheterocyclic acid derivatives to be synthesized in excellent yields and with high degrees of enantioselectivity. In addition, the effect that the nature of the nitrogen substituent has on the rate of the conjugate reduction reaction has been explored.
一种用于α,β-不饱和羰基化合物不对称共轭还原的手性氢化铜催化剂已被用于还原含有β-氮取代基的底物。一组新的反应条件使得多种β-氮杂环酸衍生物得以以优异的产率和高度的对映选择性合成。此外，还探索了氮取代基的性质对共轭还原反应速率的影响。
