Velaphi Sithembiso, Cilliers Antoinette, Beckh-Arnold Elaine, Mokhachane Mantoa, Mphahlele Ramatsimele, Pettifor John
Department of Paediatrics, University of the Witwatersrand, Johannesburg, South Africa.
J Perinatol. 2004 Apr;24(4):263-5. doi: 10.1038/sj.jp.7211050.
The common side effects associated with the use of prostaglandins in newborn infants include apnoea, hyperthermia, diarrhoea, skin flushing and oedema. Periosteal reaction or cortical thickening of the bones, also known as cortical hyperostosis, is associated with a prolonged use of prostaglandins. This is a radiological diagnosis; therefore, its occurrence is most likely underestimated. We describe an infant who developed cortical hyperostosis simulating osteomyelitis with elevated alkaline phosphatase. The radiologic changes were initially attributed to congenital syphilis. This occurred after a prolonged infusion of prostaglandin E(1) for a cyanotic congenital heart disease.
新生儿使用前列腺素的常见副作用包括呼吸暂停、体温过高、腹泻、皮肤潮红和水肿。骨膜反应或骨骼皮质增厚，也称为皮质增生，与前列腺素的长期使用有关。这是一种放射学诊断；因此，其发生率很可能被低估了。我们描述了一名出现皮质增生并伴有碱性磷酸酶升高、酷似骨髓炎的婴儿。放射学改变最初被归因于先天性梅毒。这发生在因青紫型先天性心脏病长期输注前列腺素E(1)之后。
