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Cortical hyperostosis simulating osteomyelitis after short-term prostaglandin E1 infusion.

作者信息

Kalloghlian A K, Frayha H H, deMoor M M

机构信息

Department of Paediatrics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.

出版信息

Eur J Pediatr. 1996 Mar;155(3):173-4. doi: 10.1007/BF01953932.

DOI:10.1007/BF01953932
PMID:8929722
Abstract

UNLABELLED

We describe a newborn with cyanotic congenital heart disease who developed severe cortical hyperostosis of his long bones simulating osteomyelitis with remarkable elevation of alkaline phosphatase on the 11th day of prostaglandin E1 (PGE1) infusion. Soft tissue swelling and tenderness disappeared 6 days after discontinuation of PGE1, however alkaline phosphatase remained high.

CONCLUSION

To our knowledge this is the first reported case that presented with such an acute complication of PGE1 therapy within a short period.

摘要

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本文引用的文献

1
Cortical hyperostosis: a complication of prolonged prostaglandin infusion in infants awaiting cardiac transplantation.皮质增生：等待心脏移植的婴儿长期输注前列腺素的一种并发症。
Pediatrics. 1994 Mar;93(3):417-20.
2
Prostaglandin E1 infants with ductus arteriosus-dependent congenital heart disease.患有动脉导管依赖性先天性心脏病的前列腺素E1婴儿。
Circulation. 1981 Nov;64(5):899-905. doi: 10.1161/01.cir.64.5.899.
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Side effects of therapy with prostaglandin E1 in infants with critical congenital heart disease.前列腺素E1治疗重症先天性心脏病婴儿的副作用。
Med J Armed Forces India. 2001 Apr;57(2):134-8. doi: 10.1016/S0377-1237(01)80134-9. Epub 2011 Jul 21.
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Cortical hyperostosis following long-term administration of prostaglandin E1 in infants with cyanotic congenital heart disease.患有青紫型先天性心脏病的婴儿长期使用前列腺素E1后出现皮质骨增生。
J Pediatr. 1980 Nov;97(5):834-6. doi: 10.1016/s0022-3476(80)80282-4.
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Bone changes from prostaglandin therapy.
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Soft-tissue swelling in two neonates during prostaglandin E1 therapy.
Pediatr Cardiol. 1986;7(3):157-60. doi: 10.1007/BF02424990.
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Case report 701: Prostaglandin E1 (PGE1) periostitis.病例报告701：前列腺素E1（PGE1）性骨膜炎。
Skeletal Radiol. 1991;20(8):617-9. doi: 10.1007/BF01106097.
9
Gastric-outlet obstruction induced by prostaglandin therapy in neonates.新生儿前列腺素治疗引起的胃出口梗阻。
N Engl J Med. 1992 Aug 20;327(8):505-10. doi: 10.1056/NEJM199208203270801.
10
Plain film and CT observations in prostaglandin-induced bone changes.前列腺素诱导的骨改变的平片和CT观察
Pediatr Radiol. 1992;22(4):264-6. doi: 10.1007/BF02019854.