Kumar Rajesh, Tyagi Rahul, Parmar Virinder S, Samuelson Lynne A, Kumar Jayant, Watterson Arthur C
Institute for Nano Science and Engineering Technology, Department of Chemistry, University of Massachusetts Lowell, MA 01854, USA.
Mol Divers. 2003;6(3-4):287-95. doi: 10.1023/b:modi.0000006820.04426.97.
The use of enzymes in synthetic applications has increased dramatically in the recent years and the field of polymer science is part of this trend. Synthesis of a variety of polymers using lipase catalyzed (Candida antarctica) polymerization reactions has led to a variety of new materials with interesting properties in our laboratories. This paper describes the synthesis of multi-component polyesters and mixed polymers having polyester and polyamide linkages under solvent-less conditions using Candida antarctica lipase B. The effect of a third component, i.e. a series of 1,omega-alkanediols (1,4-butanediol, 1,6-hexanediol, 1,8-octanediol, 1,10-decanediol, 1,12-dodecanediol, 1,14-tetradecanediol and 1,16-hexadecanediol) on the copolymerization reaction of dimethyl 5-hydroxyisophthalate with poly(ethylene glycol 600) has been studied and the mechanism for the incorporation of the third component is proposed. We have also studied the effect of different functional groups during terpolymerization reaction of dimethyl 5-hydroxyisophthalate with poly(ethylene glycol) by adding a third component having different functionalities (1,6-hexanediol, 1,6-hexanediamine or 1,6-hexanedithiol) and compared the effect of hydroxyl, amine and thiol groups on the polymerization reactions.
近年来，酶在合成应用中的使用急剧增加，聚合物科学领域也顺应了这一趋势。在我们的实验室中，利用脂肪酶催化（南极假丝酵母）的聚合反应合成了多种聚合物，从而得到了具有有趣特性的各种新材料。本文描述了在无溶剂条件下，使用南极假丝酵母脂肪酶B合成具有聚酯和聚酰胺键的多组分聚酯和混合聚合物。研究了第三组分，即一系列1,ω-链烷二醇（1,4-丁二醇、1,6-己二醇、1,8-辛二醇、1,10-癸二醇、1,12-十二烷二醇、1,14-十四烷二醇和1,16-十六烷二醇）对5-羟基间苯二甲酸二甲酯与聚乙二醇600共聚反应的影响，并提出了第三组分的掺入机理。我们还通过添加具有不同官能团的第三组分（1,6-己二醇、1,6-己二胺或1,6-己二硫醇），研究了5-羟基间苯二甲酸二甲酯与聚乙二醇三元共聚反应中不同官能团的影响，并比较了羟基、胺基和硫醇基对聚合反应的影响。
