Seven Huseyin, Sayin Ibrahim, Turgut Suat
Ear, Nose, and Throat Department, Sisli Etfal Training and Research Hospital, Istanbul, Turkey.
J Laryngol Otol. 2004 Mar;118(3):213-6. doi: 10.1258/002221504322927991.
This study was designed to evaluate the effects of a prophylactic antibiotic regimen on the incidence of wound infection after clean neck dissections. A prospective series of 57 patients undergoing clean neck dissections with the use of perioperative ampicillin-sulbactam for 24 hours was compared with an historical control group of 51 patients undergoing clean neck dissections with no perioperative antibiotic use. The outcome variable was the incidence of post-operative wound infection. The two groups were similar for factors reported to influence the rate of post-operative wound infection. Wound infection occurred in one patient (1.7 per cent) in the study group and in seven patients (13.3 per cent) in the control group, the difference was statistically significant (p = 0.02). These data suggest that the use of a perioperative antibiotic for 24 hours in patients undergoing clean neck dissection results in significant reduction in the incidence of post-operative wound infection.
本研究旨在评估预防性抗生素方案对颈部清洁性清扫术后伤口感染发生率的影响。将前瞻性纳入的57例行颈部清洁性清扫术且围手术期使用氨苄西林舒巴坦24小时的患者系列与历史对照组51例行颈部清洁性清扫术且围手术期未使用抗生素的患者进行比较。结果变量为术后伤口感染发生率。两组在据报道会影响术后伤口感染率的因素方面相似。研究组有1例患者发生伤口感染（1.7%），对照组有7例患者发生伤口感染（13.3%），差异具有统计学意义（p = 0.02）。这些数据表明，颈部清洁性清扫术患者围手术期使用抗生素24小时可显著降低术后伤口感染的发生率。
