Szelies B, Grond M, Herholz K, Kessler J, Wullen T, Heiss W D
Max-Planck-Institut für neurologische Forschung, Köln, Germany.
J Neurol Sci. 1992 Jul;110(1-2):46-56. doi: 10.1016/0022-510x(92)90008-9.
Quantitative analysis of topographical EEG was studied in comparison with measurement of regional glucose metabolism by PET in 42 patients with clinical diagnosis of probable dementia of Alzheimer type (AD) and in 15 age-matched normal controls. Measures analyzed included global and regional data from areas typically affected and not affected by AD pathology. While disturbance of metabolism followed a typical regional pattern, relative alpha, theta and delta power were more globally altered without selectivity for specific regions. Separation between AD and age matched controls by relative theta power was correct in 86% and was close to that by temporo-parietal glucose metabolism (correct classification 87%). Relative theta power as well as temporo-parietal glucose metabolism were significantly correlated (tau B = 0.54 and -0.53, respectively) to severity of AD assessed by the global deterioration scale. These results indicate that EEG measures may be used with an accuracy close to metabolic values from PET for the assessment of severity of AD.
对42例临床诊断为可能的阿尔茨海默病型痴呆（AD）患者和15名年龄匹配的正常对照者，研究了脑电图地形图的定量分析，并与正电子发射断层扫描（PET）测量的局部葡萄糖代谢进行比较。分析的指标包括来自AD病理通常累及和未累及区域的整体和局部数据。虽然代谢紊乱遵循典型的局部模式，但相对α、θ和δ功率在整体上改变更大，对特定区域无选择性。通过相对θ功率区分AD患者和年龄匹配的对照者，正确率为86%，接近通过颞顶叶葡萄糖代谢的区分率（正确分类率87%）。相对θ功率以及颞顶叶葡萄糖代谢与通过整体衰退量表评估的AD严重程度显著相关（tau B分别为0.54和-0.53）。这些结果表明，脑电图测量在评估AD严重程度时，其准确性可能接近PET的代谢值。
