Toksöz Hayri, Unal Selma, Kirazli Serafettin, Gürgey Aytemiz
Department of Pediatric Hematology, Hacettepe University, Ihsan Dog?ramaci Children's Hospital, 06100, Ankara, Turkey.
Leuk Res. 2004 May;28(5):533-5. doi: 10.1016/j.leukres.2003.09.012.
In order to investigate the effects of short term high dose methylprednisolone (HDMP) on fibrinolytic system in patients with ALL, 16 of newly diagnosed 32 ALL patients were given HDMP alone (20 mg/kg per day) for 5 days and the rest 16 patients received conventional dose methylprednisolone (CDMP, 2 mg/kg per day) prior to a combination chemotherapy consisting of methylprednisolone, vincristin, daunorubicin and 9 doses of l-Asparaginase. Fibrinogen levels decreased in both groups at day 5 which was statistically significant in the HDMP group. Baseline d-dimer levels of both groups were significantly higher than those of the control group including 24 healthy children. d-dimer levels significantly decreased after initiation of combination therapy in both groups. There was a significant rise in PAI-1 levels after combination therapy both in HDMP and CDMP groups.
为了研究短期大剂量甲基强的松龙（HDMP）对急性淋巴细胞白血病（ALL）患者纤溶系统的影响，32例新诊断的ALL患者中，16例单独给予HDMP（每天20mg/kg），持续5天，其余16例患者在由甲基强的松龙、长春新碱、柔红霉素和9剂左旋门冬酰胺酶组成的联合化疗前接受常规剂量甲基强的松龙（CDMP，每天2mg/kg）。两组患者在第5天时纤维蛋白原水平均下降，HDMP组具有统计学意义。两组患者的基线D-二聚体水平均显著高于包括24名健康儿童在内的对照组。两组患者在联合治疗开始后D-二聚体水平均显著下降。HDMP组和CDMP组在联合治疗后PAI-1水平均显著升高。
