Ozyurek Emel, Okur Hamza, Gurgey Aytemiz
Department of Paediatrics, Section of Haematology and Institute of Child Health, Hacettepe University Medical School, Ankara, Turkey.
Ann Hematol. 2006 Jan;85(1):55-7. doi: 10.1007/s00277-005-0016-x. Epub 2005 Oct 29.
We have investigated serum endothelin-1 (ET) and nitric oxide (NO) levels before and after a short course of high dose methylprednisolone (HDMP) in children with acute lymphoblastic leukemia (ALL) as an indicator of vasoconstrictor and vasodilator properties of endothelium. Nineteen children with ALL (aged 13-180 months; 5 girls and 14 boys) and 25 healthy children were included in the present study. The children with ALL were given HDMP (20 mg kg 1 day 1) alone for the first 5 days. Serum ET and NO levels were analysed before and after a short course of high dose methylprednisolone. Before treatment, serum ET levels (median 7.6 pg ml 1) of the patients were lower than the healthy controls (13.0 pg ml 1) (p < 0.05), and it rose to similar levels (13.0 pg ml 1) following therapy as in the controls. Nitric oxide levels (7.0 micromol) of the patients were insignificantly higher than the healthy controls (3.9 micromol) and did not differ after treatment (7.0 micromol) (p > 0.05). In conclusion, the elevation of ET to normal level following treatment suggests that a short course of high dose of methylprednisolone improve the endothelial dysfunction caused by acute leukemia.
我们研究了急性淋巴细胞白血病（ALL）患儿在短期大剂量甲基强的松龙（HDMP）治疗前后的血清内皮素-1（ET）和一氧化氮（NO）水平，以此作为内皮血管收缩和舒张特性的指标。本研究纳入了19名ALL患儿（年龄13 - 180个月；5名女孩和14名男孩）和25名健康儿童。ALL患儿在最初5天单独给予HDMP（20 mg·kg⁻¹·d⁻¹）。在短期大剂量甲基强的松龙治疗前后分析血清ET和NO水平。治疗前，患者的血清ET水平（中位数7.6 pg·ml⁻¹）低于健康对照组（13.0 pg·ml⁻¹）（p < 0.05），治疗后升至与对照组相似的水平（13.0 pg·ml⁻¹）。患者的一氧化氮水平（7.0 μmol）略高于健康对照组（3.9 μmol），治疗后无差异（7.0 μmol）（p > 0.05）。总之，治疗后ET升高至正常水平表明短期大剂量甲基强的松龙可改善急性白血病所致的内皮功能障碍。
