健康对照人群中代谢基因多态性与烟草消费的关联

Association of metabolic gene polymorphisms with tobacco consumption in healthy controls.

作者信息

Smits Kim M, Benhamou Simone, Garte Seymour, Weijenberg Matty P, Alamanos Yannis, Ambrosone Christine, Autrup Herman, Autrup Judith L, Baranova Helena, Bathum Lisa, Boffetta Paolo, Bouchardy C, Brockmoller Jurgen, Butkiewicz Dorota, Cascorbi Ingolf, Clapper Margie L, Coutelle Christiane, Daly Ann K, Muzi Giacomo, Dolzan Vita, Duzhak Tatyana G, Farker Katrin, Golka Klaus, Haugen Aage, Hein David W, Hildesheim Allan, Hirvonen Ari, Hsieh Ling L, Ingelman-Sundberg Magnus, Kalina Ivan, Kang Daehee, Katoh Takahiko, Kihara Masahiro, Ono-Kihara Masako, Kim Heon, Kiyohara Chikako, Kremers Pierre, Lazarus Philip, Le Marchand Loic, Lechner Maria C, London Stephanie, Manni Johannes J, Maugard Christine M, Morgan Gareth J, Morita Shunji, Nazar-Stewart Valle, Kristensen Vessela Nedelcheva, Oda Yoshio, Parl Fritz F, Peters Wilbert H M, Rannug Agneta, Rebbeck Timothy, Pinto Luis F Ribeiro, Risch Angela, Romkes Marjorie, Salagovic Jan, Schoket Bernadette, Seidegard Janeric, Shields Peter G, Sim Edith, Sinnett Daniel, Strange Richard C, Stucker Isabelle, Sugimura Haruhiko, To-Figueras Jordi, Vineis Paolo, Yu Mimi C, Zheng Wei, Pedotti Paola, Taioli Emanuela

机构信息

University Maastricht, Maastricht, The Netherlands.

出版信息

Int J Cancer. 2004 Jun 10;110(2):266-70. doi: 10.1002/ijc.20114.

DOI:10.1002/ijc.20114

PMID:15069692

Abstract

Polymorphisms in genes that encode for metabolic enzymes have been associated with variations in enzyme activity between individuals. Such variations could be associated with differences in individual exposure to carcinogens that are metabolized by these genes. In this study, we examine the association between polymorphisms in several metabolic genes and the consumption of tobacco in a large sample of healthy individuals. The database of the International Collaborative Study on Genetic Susceptibility to Environmental Carcinogens was used. All the individuals who were controls from the case-control studies included in the data set with information on smoking habits and on genetic polymorphisms were selected (n = 20938). Sufficient information was available on the following genes that are involved in the metabolism of tobacco smoke constituents: CYP1A1, GSTM1, GSTT1, NAT2 and GSTP1. None of the tested genes was clearly associated with smoking behavior. Information on smoking dose, available for a subset of subjects, showed no effect of metabolic gene polymorphisms on the amount of smoking. No association between polymorphisms in the genes studied and tobacco consumption was observed; therefore, no effect of these genes on smoking behavior should be expected.

摘要

编码代谢酶的基因多态性与个体间酶活性的差异有关。这种差异可能与个体接触由这些基因代谢的致癌物的差异有关。在本研究中，我们在一大群健康个体中检测了几个代谢基因的多态性与烟草消费之间的关联。使用了国际环境致癌物遗传易感性协作研究数据库。从数据集中纳入的病例对照研究中选取所有作为对照且有吸烟习惯和基因多态性信息的个体（n = 20938）。对于以下参与烟草烟雾成分代谢的基因有足够的信息：CYP1A1、GSTM1、GSTT1、NAT2和GSTP1。所检测的基因均未与吸烟行为有明显关联。部分受试者有吸烟剂量信息，结果显示代谢基因多态性对吸烟量没有影响。在所研究的基因多态性与烟草消费之间未观察到关联；因此，不应预期这些基因对吸烟行为有影响。