Zhao Jun-Gong, Feng Gan-Sheng, Kong Xiang-Quan, Li Xin, Li Ming-Hua, Cheng Ying-Sheng
Department of Radiology, Sixth Affiliated Hospital of Shanghai Jiaotong University, Shanghai 200233, China.
World J Gastroenterol. 2004 Apr 15;10(8):1152-6. doi: 10.3748/wjg.v10.i8.1152.
To assess the vascularity of hepatocellular carcinoma (HCC) before and after transcatheter arterial chemoembolization (TACE) with the quantitative parameters obtained by first pass perfusion weighted MR imaging (FP-MRI).
Seventeen consecutive patients with one to three lesions in liver underwent FP-MRI before treatment. FP-MRI was also performed one, three, six, nine months, and one year after TACE. The baseline signal intensity (S0) of pre-TACE and one month after TACE was analyzed, the vascularity of HCC assessed by steepest slope of the signal intensity versus time curves (SS) was blindly correlated with their DSA feature and clinical outcome.
No significant difference was found on baseline signal intensity (S0) between pre-TACE and one month after TACE (F=0.309, P=0.583), The SS (mean, 32% per second) of lesion one month after TACE was lower than that of pre-TACE (mean, 69% per second), but with no statistical significance (F=3.067, P=0.092). When local recurrence occurred, the time intensity curves became steeper. The vascularity of HCC before and after TACE graded by SS closely correlated with that by DSA (K=0.453, P<0.05).
FP-MRI is a useful criterion for selecting effective interventional treatment for patients with HCC in their initial treatment and during follow up.
采用首次通过灌注加权磁共振成像（FP-MRI）获得的定量参数，评估经导管动脉化疗栓塞术（TACE）前后肝细胞癌（HCC）的血管情况。
17例肝脏有1至3个病灶的连续患者在治疗前接受了FP-MRI检查。TACE术后1个月、3个月、6个月、9个月及1年也进行了FP-MRI检查。分析TACE术前及术后1个月的基线信号强度（S0），通过信号强度-时间曲线的最大斜率（SS）评估HCC的血管情况，并将其与DSA特征及临床结果进行盲法相关性分析。
TACE术前与术后1个月的基线信号强度（S0）无显著差异（F = 0.309，P = 0.583），TACE术后1个月病灶的SS（平均每秒32%）低于术前（平均每秒69%），但无统计学意义（F = 3.067，P = 0.092）。当出现局部复发时，时间-强度曲线变得更陡。通过SS对TACE前后HCC血管情况的分级与DSA分级密切相关（K = 0.453，P < 0.05）。
FP-MRI是为HCC患者在初始治疗及随访期间选择有效介入治疗的有用标准。
