游离磺化铝酞菁及其与单克隆抗体的缀合物的荧光和吸收光谱的pH依赖性
pH dependence of fluorescence and absorbance spectra of free sulphonated aluminium phthalocyanine and its conjugate with monoclonal antibodies.
作者信息
Savitsky A P, Lopatin K V, Golubeva N A, Chernyaeva E B, Stepanova N V, Solovieva L I, Lukyanets E A
机构信息
A. N. Bakh Institute of Biochemistry, Russian Academy of Sciences, Moscow.
出版信息
J Photochem Photobiol B. 1992 May 15;13(3-4):327-33. doi: 10.1016/1011-1344(92)85073-4.
PMID:1506995
Abstract
Water-soluble phthalocyanines and phthalocyanines linked to targeting monoclonal antibodies are considered to be one of the most promising photosensitizers in photodynamic therapy. Here the spectrum characteristics of sulphonated aluminium phthalocyanine and its protein conjugate in the pH range 1.8-12.0 in solution have been studied. The pK values are determined.
摘要
水溶性酞菁以及与靶向单克隆抗体相连的酞菁被认为是光动力疗法中最有前景的光敏剂之一。本文研究了磺化铝酞菁及其与蛋白质的共轭物在溶液中pH值范围为1.8至12.0时的光谱特性，并测定了pK值。
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