Kanwar K C, Tikoo A
Department of Biophysics, Panjab University, Chandigarh, India.
J Environ Pathol Toxicol Oncol. 1992 Jul-Aug;11(4):241-5.
Hematological fluctuations following large alcohol oral administration (2 mL per animal per day) in rats were monitored at intervals ranging from 10 to 22 weeks and the findings were compared to those in control animals that were fed sucrose isocalorically. Following alcohol ingestion, there was a significant decrease in the total blood cellularity at all treatment intervals. A fall in the erythrocyte count per millimeter3 was accompanied by decreased hematocrit values and hemoglobin levels in the alcohol-treated animals. On the other hand, the MCV and MCH values were significantly elevated after alcohol ingestion. Despite overall leukopenia observed after alcohol ingestion, there was a significant increase in the absolute neutrophil count. The absolute lymphocyte count, however, fell significantly in the alcohol-treated animals. Eosinophils and basophils were not significantly altered by alcohol toxicity.
对大鼠口服大量酒精（每只动物每天2毫升）后10至22周期间的血液学波动进行监测，并将结果与等热量喂食蔗糖的对照动物进行比较。摄入酒精后，在所有治疗间隔期全血细胞计数均显著下降。酒精处理组动物每立方毫米红细胞计数下降，同时血细胞比容值和血红蛋白水平降低。另一方面，摄入酒精后平均红细胞体积（MCV）和平均红细胞血红蛋白含量（MCH）值显著升高。尽管摄入酒精后观察到总体白细胞减少，但绝对中性粒细胞计数显著增加。然而，酒精处理组动物的绝对淋巴细胞计数显著下降。酒精毒性对嗜酸性粒细胞和嗜碱性粒细胞没有显著影响。
