Kanwar K C, Raina P
Biophysics Department, Panjab University, Candigarh, India.
J Environ Pathol Toxicol Oncol. 1988;8(7 Spec No):1-5.
Haematological lesions (viz. total leukocyte count, differential leukocyte count, RBC count, haematocrit value) have been studied in both adults and freshly weaned rat pups following heavy oral (50 mg/kg b.wt.) lithium administration for 2 months. Significant increase in the total leukocyte count/mm3 and neutrophil count/mm3 accompanied by concomitant fall in the lymphocyte count/mm3 was observed in both the adults and weaned rat pups at all the treatment intervals. Erythrocyte count and the haematocrit values were also significantly increased in both the treated adults and pups as compared to their age matched controls. Physiological significance of these haematological fluctuations has been discussed.
在成年大鼠和刚断奶的幼鼠中，研究了口服大剂量（50毫克/千克体重）锂2个月后的血液学病变（即白细胞总数、白细胞分类计数、红细胞计数、血细胞比容值）。在所有治疗间隔期，成年大鼠和断奶幼鼠的白细胞总数/立方毫米和中性粒细胞计数/立方毫米均显著增加，同时淋巴细胞计数/立方毫米相应下降。与年龄匹配的对照组相比，接受治疗的成年大鼠和幼鼠的红细胞计数和血细胞比容值也显著增加。文中讨论了这些血液学波动的生理意义。
