Rodrick Dani, Dillon Belinda, Dexter Mark, Nicholson Ian, Marcel Sebastien, Dickeson David, Iredell Jon
Westmead Private Hospital, Sydney, New South Wales, Australia.
J Clin Microbiol. 2004 Apr;42(4):1846-8. doi: 10.1128/JCM.42.4.1846-1848.2004.
A 44-year-old man with a bioprosthetic aortic valve suffered destructive endocarditis with severe embolic disease due to Bartonella henselae infection. Multilocus sequence typing was successfully performed with crude preparations of operative tissue as templates, and the infecting organism was determined to be typical of the Houston clonal group, although it was never cultured from blood or tissue. This is the first report of B. henselae infection in the South Pacific, and it reminds one that B. henselae is a cause of potentially lethal culture-negative endocarditis which may respond poorly to conventional empirical therapy. Nothing is known of the epidemiology of the infection in this region, but it is likely to be common and to contain representatives of both major clonal complexes. This study emphasizes the ease with which multilocus sequence typing can be used directly with tissue, which is important because of suggestions of strain-dependent clinical outcomes.
一名44岁植入生物人工主动脉瓣的男性因汉赛巴尔通体感染患上了破坏性心内膜炎，并伴有严重的栓塞性疾病。以手术组织粗提物为模板成功进行了多位点序列分型，确定感染病原体属于休斯顿克隆群的典型类型，尽管从未从血液或组织中培养出该病原体。这是南太平洋地区关于汉赛巴尔通体感染的首例报告，它提醒人们，汉赛巴尔通体是潜在致命的培养阴性心内膜炎的病因之一，可能对传统经验性治疗反应不佳。目前对该地区这种感染的流行病学情况尚不清楚，但很可能很常见，且包含两个主要克隆复合体的代表菌株。这项研究强调了多位点序列分型可直接用于组织的简便性，鉴于有研究表明菌株与临床结果相关，这一点很重要。
