Govindaraju V, Manjunath C N, Sundar Kumar K
Sri Jayadeva Institute of Cardiology, Bangalore 560069.
J Indian Med Assoc. 2003 Aug;101(8):458-60, 462.
Prevalence of coronary artery disease (CAD) in Indian population is gradually increasing at an alarming rate. Traditional risk factors fail to explain the high incidence of CAD. Although lipoprotein(a) has been shown to be a risk factor for atherosclerosis, there is very limited data regarding Indian patients. The present study was therefore undertaken to assess the role of lipoprotein(a) levels as a risk factor in CAD in Indian patients. Clinical profile, lipid profile, coronary angiography and lipoprotein(a) levels were assessed in 300 patients with CAD and 200 controls with no CAD. There was no significant difference in age, conventional risk factors like diabetes, hypertension, smoking, family history and lipid parameters between the two groups. The mean plasma lipoprotein(a) levels in patients with CAD was 32.18 +/- 1.37 mg/dl. The value was not significantly higher than that of the mean of 29.94 +/- 2.59 mg/dl of lipoprotein(a) in the control group. In the subgroup of diabetics and patients with myocardial infarction there was a trend towards increased lipoprotein(a) levels compared to controls but the difference was not statistically significant. Nor there was any relationship between lipoprotein(a) levels and number of stenosed coronary arteries. Thus the study shows that lipoprotein(a) levels do not significantly correlate with the presence of coronary artery disease.
印度人群中冠状动脉疾病（CAD）的患病率正以惊人的速度逐渐上升。传统风险因素无法解释CAD的高发病率。尽管脂蛋白（a）已被证明是动脉粥样硬化的一个风险因素，但关于印度患者的数据非常有限。因此，本研究旨在评估脂蛋白（a）水平作为印度CAD患者风险因素的作用。对300例CAD患者和200例无CAD的对照者进行了临床特征、血脂谱、冠状动脉造影和脂蛋白（a）水平评估。两组在年龄、糖尿病、高血压、吸烟、家族史等传统风险因素以及血脂参数方面无显著差异。CAD患者的平均血浆脂蛋白（a）水平为32.18±1.37mg/dl。该值并不显著高于对照组脂蛋白（a）平均水平29.94±2.59mg/dl。在糖尿病亚组和心肌梗死患者中，与对照组相比脂蛋白（a）水平有升高趋势，但差异无统计学意义。脂蛋白（a）水平与冠状动脉狭窄数量之间也无任何关系。因此，该研究表明脂蛋白（a）水平与冠状动脉疾病的存在无显著相关性。
