Geethanjali F S, Jose V Jacob, Kanagasabapathy A S
Department of Cardiology and Clinical Biochemistry, Christian Medical College Hospital, Vellore.
Indian Heart J. 2002 Jan-Feb;54(1):50-3.
Plasma lipoprotein (a) levels in the Indian population are varied; this study was undertaken to determine the relationship between plasma lipoprotein (a) levels and their phenotypes in a group of south Indian patients with coronary artery disease.
A total of 104 patients with angiographically proven coronary artery disease were compared with 104 age- and sex-matched controls with no risk factors such as hypertension, diabetes and smoking. Lipoprotein (a) levels were measured by an in-house ELISA method and its phenotyping was done by SDS agarose gel electrophoresis. Plasma lipoprotein (a) levels were significantly elevated in patients with coronary artery disease as compared to controls (33.4+/-26.1 mg/dl v. 21.4+/-12.8 mg/dl; p<0.01). Lipoprotein (a) phenotyping showed that low-molecular weight isoforms were found only in 19.2% of the patients with coronary artery disease and their plasma lipoprotein (a) levels were significantly elevated compared to coronary artery disease patients with higher molecular weight isoforms (50.9+/-34.2 mg/dl v. 29.24+/-20.06 mg/dl; p<0.001).
Plasma lipoprotein (a) levels are significantly elevated in patients with coronary artery disease as compared to controls. The commoner phenotype in a South Indian population is the larger apolipoprotein (a). in which the lipoprotein (a) levels are lower. Hence the contribution of lipoprotein (a) phenotype to the lipoprotein (a) levels in our population, if any, is modest.
印度人群的血浆脂蛋白(a)水平各不相同；本研究旨在确定一组南印度冠心病患者的血浆脂蛋白(a)水平与其表型之间的关系。
将104例经血管造影证实患有冠心病的患者与104例年龄和性别匹配、无高血压、糖尿病和吸烟等危险因素的对照者进行比较。采用内部酶联免疫吸附测定法测量脂蛋白(a)水平，并通过十二烷基硫酸钠琼脂糖凝胶电泳对其进行表型分析。与对照组相比，冠心病患者的血浆脂蛋白(a)水平显著升高(33.4±26.1mg/dl对21.4±12.8mg/dl；p<0.01)。脂蛋白(a)表型分析显示，低分子量亚型仅在19.2%的冠心病患者中发现，与高分子量亚型的冠心病患者相比，其血浆脂蛋白(a)水平显著升高(50.9±34.2mg/dl对29.24±20.06mg/dl；p<0.001)。
与对照组相比，冠心病患者的血浆脂蛋白(a)水平显著升高。在南印度人群中较常见的表型是较大的载脂蛋白(a)，其中脂蛋白(a)水平较低。因此，脂蛋白(a)表型对我国人群脂蛋白(a)水平的贡献(如果有的话)是适度的。
