Hastak S M
Lilavati Hospital, Mumbai 400 050.
J Indian Med Assoc. 2003 Aug;101(8):500-1.
Age-related dopamine decline leads to memory impairment, vertigo or tinnitus leading to a reduced quality of life in the elderly. This study demonstrates the efficacy and acceptability of piribedil, a dopamine agonist, in improving these conditions. Of the 515 patients included in the study, there was complete resolution of memory impairment, vertigo and tinnitus in 103 patients (20%), improvement in 374 cases (72.6%), with 38 cases (7.4%) showing no change after one month's treatment with piribedil. The treatment was well accepted with a low frequency of side-effects and full compliance with daily medication.
与年龄相关的多巴胺减少会导致记忆障碍、眩晕或耳鸣，从而降低老年人的生活质量。本研究证明了多巴胺激动剂吡贝地尔在改善这些症状方面的有效性和可接受性。在纳入研究的515例患者中，103例（20%）的记忆障碍、眩晕和耳鸣完全消失，374例（72.6%）有所改善，38例（7.4%）在接受吡贝地尔治疗1个月后无变化。该治疗的接受度良好，副作用发生率低，患者完全依从每日用药。
