Azevedo Andréia A, Figueiredo Ricardo R
OTOSUL, Otorrinolaringologia Sul-Fluminense, Hospital São Camilo, Volta Redonda, RJ.
Braz J Otorhinolaryngol. 2005 Sep-Oct;71(5):618-23. doi: 10.1016/s1808-8694(15)31266-0. Epub 2006 Mar 31.
Nowadays, the treatment of tinnitus is still a great challenge for the otolaryngologists. Many facts remain unknown in its pathophysiology, leading to many different therapies, with irregular results. Acamprosate is a drug used in alcoholism treatment, due to its regulating effects in glutamatergic and GABA neurotransmission, and has never been used before in the treatment of tinnitus
To evaluate efficacy and safety of the acamprosate in the treatment of sensorineural tinnitus.
Randomized clinical trial.
50 patients with sensorineural tinnitus were divided into two groups: 25 received acamprosate and 25 placebo, for a period of 3 months, in a prospective double-blind study, being analyzed for its efficacy and safety by the subjective score from 1 to 10 given by the patient.
We found a high index of success in the relief of tinnitus, about 86.9%. In 47.8% of the cases we found more than 50% relief. The incidence of side effects was low, 12%, all of them mild.
Acamprosate, a drug used in the treatment of alcoholism, is a safe and successful alternative for sensorineural tinnitus' treatment.
如今，耳鸣的治疗对耳鼻喉科医生来说仍是一项巨大挑战。其病理生理学中的许多事实仍不为人知，导致了许多不同的疗法，但效果参差不齐。阿坎酸是一种用于治疗酒精中毒的药物，因其对谷氨酸能和γ-氨基丁酸神经传递有调节作用，此前从未用于治疗耳鸣。
评估阿坎酸治疗感音神经性耳鸣的疗效和安全性。
随机临床试验。
50例感音神经性耳鸣患者被分为两组：25例接受阿坎酸治疗，25例接受安慰剂治疗，为期3个月，在一项前瞻性双盲研究中，通过患者给出的1至10分主观评分来分析其疗效和安全性。
我们发现耳鸣缓解的成功率很高，约为86.9%。在47.8%的病例中，我们发现耳鸣缓解超过50%。副作用发生率较低，为12%，且均为轻度。
阿坎酸，一种用于治疗酒精中毒的药物，是治疗感音神经性耳鸣的一种安全且成功的选择。
