Capra M, Wherrett D, Weitzman S, Dirks P, Hawkins C, Bouffet E
Division of Haematology/Oncology, Hospital for Sick Children, Toronto, Canada.
J Neurooncol. 2004 Mar-Apr;67(1-2):227-31. doi: 10.1023/b:neon.0000021863.06620.48.
We report a 14-year-old girl in whom a diagnosis of primary central nervous system lymphoma was confirmed while receiving growth hormone (GH) for GH deficiency, detected after presenting with short stature. MRI revealed an enhancing and thickened pituitary stalk with absence of the normal bright signal in the posterior pituitary. Regular MRI surveillance detected progression of the neurohypophyseal changes 13 months into GH treatment. Biopsy confirmed this to be B-cell large cell lymphoma. This case highlights the diagnostic and management challenges inherent in treating such children.
我们报告了一名14岁女孩，她因身材矮小被诊断为生长激素（GH）缺乏症，在接受GH治疗期间确诊为原发性中枢神经系统淋巴瘤。MRI显示垂体柄强化增厚，垂体后叶正常高信号消失。在GH治疗13个月时，定期MRI监测发现神经垂体病变进展。活检证实为B细胞大细胞淋巴瘤。该病例凸显了治疗此类儿童所固有的诊断和管理挑战。
